The first trimester: prediction and prevention of the great obstetrical syndromes

Best Pract Res Clin Obstet Gynaecol. 2015 Feb;29(2):183-93. doi: 10.1016/j.bpobgyn.2014.09.006. Epub 2014 Oct 14.

Abstract

A number of groups are currently examining the potential of screening for pre-eclampsia and gestational diabetes at 12 weeks' gestation. This can be performed at the time of combined first-trimester screening for aneuploidy using a similar method of regression analysis to combine multiple demographic and investigative factors. At present, research into the prediction of pre-eclampsia is more robust and is associated with the potential for therapeutic intervention that can reduce the prevalence of early-onset pre-eclampsia and improve maternal and neonatal outcomes.

Keywords: first-trimester pregnancy; gestational diabetes; pre-eclampsia; screening.

Publication types

  • Review

MeSH terms

  • Biomarkers / blood
  • Decision Support Techniques
  • Diabetes, Gestational / blood
  • Diabetes, Gestational / diagnosis*
  • Diabetes, Gestational / prevention & control*
  • Early Diagnosis
  • Female
  • Humans
  • Pre-Eclampsia / blood
  • Pre-Eclampsia / diagnosis*
  • Pre-Eclampsia / prevention & control*
  • Pregnancy
  • Pregnancy Trimester, First*
  • Prenatal Diagnosis / methods*
  • Risk Assessment
  • Syndrome

Substances

  • Biomarkers